Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: Differential subcellular localization and regulated expression by cyclic AMP
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چکیده
منابع مشابه
Expression of Recombinant Phosphodiesterase 3A and 3B Using Baculovirus Expression System
Background: Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. Objectives: In th...
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In a suitable environment spores of the Dictyostelia [ 1 ] germinate yielding small amoebae. Each amoebae feeds on bacteria and divides. Following consumption of the food supply amoebae aggregate forming a slug where cells differentiate into spores and stalk ceils. The orientation of cells towards a food source or an aggregation center is guided by gradients of concentration of chemotactic mole...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1998
ISSN: 0007-1188,1476-5381
DOI: 10.1038/sj.bjp.0702227